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In Vivo Imaging
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Project Introduction

 小动物活体成像mainlyadopting生物发光 (bioluminescence) with荧光 (fluorescence) 两种技术. mainlyisutilizing一套sensitiveof光学detectinstrument,can直接监控生物体内cell活动andgene行for,观测活体动物体内肿瘤of生长及转移,感染性疾病发展过程, 特定geneof表达etc.生物学过程. 其优点for较传统屠宰动物相比, 该技术be able to对同一种实验对象in不同时间点进行record, 跟踪同一observe目标 (标记cell及gene) of移动及变化, 所得of数据more真实可信.

     mainly应用于癌症with抗癌药物research; 免疫学with干cellofresearch; cell凋亡; 病理机制及virusresearch; gene表达andprotein之间相互作用; 转gene动物模型构建; 药效评估; 药物甄选with预临床检验; 药物配方with剂量管理; 肿瘤学应用; 生物光子学detectetc..


Project Cases

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Sample Requirements

测试前需and技术人员联系,需provide待测样品and完善of实验方案 (平台也可according to实验要求出实验方案) , 明确样品浓度and剂量, 给药方式, 动物模型etc.信息.


FAQ

    1, such as何能detect到体内发出of可见光?

    A: 两pcsmainlyof原因be able to保证可见光成像技术be able todetect到体内发出of微弱of可见光.a: 高Sensitivityof制冷CCD镜头, 可达到零下-105℃, 体内发出ofvery少of光子也能detect得到. b: 绝对密封of暗箱装置, can屏蔽including射线in内of所have光线.

    2, 大鼠可否用作活体成像实验?

    A: 成体老鼠and裸鼠, 幼鼠及胚胎of区别只in于对可见光of穿透性不同, 可见光of穿透能力in3-4cm之间, 所以大鼠也can作for活体成像of动物, 关于大鼠活体成像已have很多文章发表.

    3, using麻醉剂麻醉动物have什么优势?

    A: 麻醉机麻醉系统相对于腹腔注射对于小鼠of麻醉in时间and精度上of控制更accurate, using也moreconvenient.

    4, with传统技术相比, 生物发光成像技术优势体现in哪些方面?

    A: with传统技术相比, 该技术对于肿瘤转移ofresearch, gene治疗, 流行病学of发病学research, 干cell示踪, 白血病of相关researchetc.方面, 用该技术进行肿瘤of药效research, 比传统方法更sensitive, 还canthrough一系列转gene动物疾病模型, 来rapid直观of进行相关疾病of发病机理and药物screenresearch.


 
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