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Project Introduction
应用场景
inprotein互作网络中, 连通性高of区域 (模块) 可能经常代表着protein复合物或某些功能通路of组成部分, 这些模块可用于预测实验关键调节生物过程或核心protein簇.
Analysis Method
throughwithSTRINGprotein网络互作数据库比对后, 提取confidence score > 0.7 (high confidence) ofprotein集合互作关系, 用Cytoscape软件对protein互作网络进行可视化. 然后usingMCODE插件挖掘网络中具have高连通性of模块, 进而对模块中ofprotein进行功能富集analyze, 标记出每pcs模块可能参withof关键生物过程.
Project Cases
图表展示
注: 差异protein互作网络功能模块analyze.网络中of点代表差异表达protein, 红色代表差异上调, 蓝色代表差异下调, 点of大小代表互作proteinofpcs数. 网络图中突出展示了三pcs高连通性of模块及其参withof生物功能.
Sample Requirements
need撰写需求文件, 提交protein序列或protein序列号, 并提前with工程师沟通联系.
FAQ
参考文献
An automated method for finding molecular complexes in large protein interaction network.
