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酰基肉碱 (Acylcarnitine) is一种类氨基酸物质with脂肪酸结合ofhave机化合物, in线粒体能量学andβ-氧化中具haveimportant作用. 肉碱将β-氧化过程中形成of乙酰基团转移到cell质中, 并协助脂肪酸从cell质中转移到线粒体以产生能量. 酰基肉碱被认forin大脑of代谢功能中发挥important作用, 参with线粒体功能and能量代谢, 抗氧化功能and膜stable性, gene表达, 神经传递and神经保护, in中枢神经系统中发挥作用.
LC-MS/MS平台可accurate定性定量detect各类样本中of酰基肉碱类靶向代谢物42种, 该方法Sensitivity高, Accuracy高且通量高.
生物Detection Indicators:
NO. | 代谢物名称 | 英文名 |
1 | 肉碱 | Free-carnitine |
2 | 乙酰肉碱 | Acetyl-carnitine C2 |
3 | 丙烯酰肉碱 | Acrylyl-carnitine C3:1 |
4 | 丙酰肉碱 | Propionyl-carnitine C3 |
5 | 丁酰肉碱 | Butyryl-carnitine C4 |
6 | 戊烯酰肉碱 | Tiglyl-carnitine C5:1 |
7 | 异戊酰肉碱 | Isovaleryl-carnitine C5 |
8 | 3-羟基-丁酰肉碱 | 3-OH-butyryl-carnitine C4-OH |
... | ... | ... |
42 | 硬脂酰-肉碱 | Stearoyl-carnitine C18 |
应用方向:
表型组and生理功能research;
临床早期预测, 诊疗research;
病理学research;
days然药物and药理research;
中医现代化and理论research;
食品科学, safeand营养学research;
畜牧业and农林业research;
植物学and环境research;
毒理学research.
参考案例:
Ahmed AT, MahmoudianDehkordi S, Bhattacharyya S, et al. Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes. J Affect Disord. 2020;264:90-97
